Bioprocess Pharmaceutical Filtration

Protecting Your Process From Mycoplasma Contamination

Plant shutdown, a shortage of key products, patients unable to access important drugs, profits hit … the consequences of a biological contamination can be devastating for a...

Eliminating Leaks and Faults: Single-Use vs Stainless Steel Systems

Ensuring process integrity – which means being able to effectively test for leaks – is a critical factor in biopharmaceutical manufacturing processes, especially given the high value placed on drug...

Automated Single-Use Technology and Its Impact on Quality

Taking steps to understand and control process variation is crucial to biopharmaceutical manufacturers. The sentiment behind the old adage, "the product is the process" can’t be dismissed.  ...

Five Critical Challenges in Single-Use Bioprocessing

Single-use technology plays an integral part in nearly all bio-production processes, yet several challenges remain —challenges which are serious enough to delay or even stop the use of single-use...

Process Protection: What Does It Mean to You?

Imagine the scenario: Your new blockbuster drug is making a significant difference to the lives of patients. But then your supply chain fails, taking the product out of circulation. The consequences...

Engineering Managers: Streamline Your Bioprocess With Automation

Twenty years ago, Professor Bernhard Sonnleitner, of the Institute of Chemistry and Biological Chemistry at the Zürich University of Applied Sciences, suggested that the bioprocess industry would...

What's Stopping You From Automating Your Single-Use Process?

The use of automation in running complex single-use systems has many benefits such as process control and consistency, increased speed, reduced labour costs and operational flexibility....

Overcoming Barriers to Single-Use Implementation

Single-use technologies have emerged as a significant and growing resource in the biopharmaceutical industry but there is still some trepidation around their use, meaning that some manufacturers are...

Design Space and its Use in Single-use Bioprocessing

The design space - a toolbox of validated parts and assemblies - allows an end-user to build any single-use device needed, utilizing a combination of validated parts.    Tubing, filters, connectors...

How Can Biomanufacturers Achieve Standardization of Single-use Assemblies

Major delays in getting products to market, higher costs generated by design, testing, and management, increased lead times due to low-volume production runs and the changeover processes...

Has Single-use Customization Gone too Far?

Single-use technology (SUT) has been adopted on a global scale since its introduction 20 years ago and its benefits are well-recognized.   Thousands of single-use products are now in use and entire...

Four Sources of Process Variation in Biopharmaceutical Manufacturing

Given the difficulty of linking the molecular structure of a complex biopharmaceutical to its efficacy and safety, the industry must maintain that “the process is the product”. Any change to...

Is Standardization Possible in a Custom Single-use World? | Poll Results

A recent Parker domnick hunter webinar discussed the question "Is Standardization Possible in a Custom Single-use World?". The webinar looked at how high levels of customization has led to...

How to Scale-up Pharmaceutical Filtration Systems | Case Study

For biomanufacturers, using a structured, analytical approach to process scale-up will breed confidence and ensure quality.    By adopting robust experimental design, results gleaned during initial...

Effective Filtration of Biopharmaceutical Buffers

Buffers are used throughout the production of pharmaceuticals and buffer filtration is essential in protecting downstream chromatography and ultrafiltration equipment, controlling bioburden throughout...

The Role of Prefiltration in the Optimization of Bioprocess Filtration Systems

Filtration is commonly used in biopharmaceutical manufacturing in order to control bioburden within the production process, and the appropriate use of prefilters can help to optimize filtration costs....

A Case Study for Collaborative Filter Product Development

Parker domnick hunter is committed to increasing productivity and customer satisfaction through application-driven new product development, and collaboration is a highly effective way in which to...

Controlling Supply Chain and Process Risk During Biomanufacturing

Imagine the scenario: an insulin production facility is forced to shut down, or production ceases, limiting the availability of insulin to diabetics around the world. It’s a disturbing picture and...

How to Select the Right Filter for Your Bioprocess

Selection of the appropriate filter product for a given application in your bioprocess is critical, as an incorrect decision at the specification stage may have significant economic, quality...

What is Sterilizing Filtration and Why is it Important?

Sterilizing filtration is now commonplace in pharmaceutical manufacturing and is used in order to prevent microbial contamination from negatively impacting drug quality and, more importantly, to...