Bioprocessing and Pharmaceutical Filtration
Optimizing Filtration of Bulk Biopharmaceutical Drugs
In bulk dispense operations, filtration can sometimes be treated as either a completely separate unit operation or in some systems as a bolt-on – an optional module that while performing this critical...
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Sterilization of Cell Culture Media - Taking on the Challenges
Cell culture media is a key component of upstream bioprocessing needed to encourage the growth and survival of cells. This is vital to achieving a viable cell density and, ultimately, the...
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Single-Use Automation in Action: The Benefits for Filtration Operations
Single-use technology has major benefits for the biopharmaceutical manufacturing industry. It enables rapid turnaround times between batches and allows facilities to be multi-product while...
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How Automation Takes Single-Use Technology to the Next Level
As the benefits of single-use became clear and the technology became established in the 2000s, there was a drive to utilize it in more process steps. Single-use was being utilized in steps...
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Reducing Human Error in Bioprocessing
Human error in bioprocessing can have serious consequences for biopharmaceutical manufacturers. Accidents can cause a health hazard for staff involved in bioprocessing operations and human error can...
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The Cost of Failing to Protect Your Final Biopharmaceutical Product
During downstream processing, the value of a product increases with every unit step of the operation, designed to both remove impurities and concentrate the biologically active component. Each of...
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Innovation Center Delivers Filtration Engineering Breakthroughs
The Parker Filtration Innovation Center houses the research and development for all of Parker Hannifin's filtration products. This 82,000 square foot facility is dedicated solely to the discovery of...
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Optimizing a Cell Culture Media Filtration Process | Case Study
A biopharmaceutical customer was reviewing its process for tryptone soya broth (TSB) and vegetable soya broth (VSB) production. The existing process incorporated five-step filtration, using...
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Standardization and Control - Protecting Your People, Product and Reputation
“It takes 20 years to build a reputation and five minutes to ruin it”. Wise words from Warren Buffet. And in biopharmaceutical manufacturing, these words certainly ring true. Process variation or...
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Improve Accuracy and Efficiency by Tackling the Eight Wastes of Lean
The principles and practices of lean manufacturing are widely used in industries across the globe to continuously improve processes, drive efficiencies and reduce costs. Even in...
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Mycoplasma Contamination - Detection and Elimination
When compared to bacterial contamination, Mycoplasma contamination isn't immediately obvious. The outcome of any contamination event is the same — the disposal of the contaminated media...
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Preventing Product Losses During Biopharmaceutical Manufacturing
In a world where we measure on-time delivery, is 98 percent really acceptable? It sounds good but in the supply chain of the pharmaceutical industry, what is the impact on the 2 percent of patients...
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Mycoplasma Contamination - Why So Serious?
Mycoplasma contamination poses a serious threat to biopharmaceutical manufacturers. But it's the specific characteristics of Mycoplasma that make it such a challenge. Mycoplasma characteristics differ...
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Tackling the Source of Mycoplasma Contamination in Biopharmaceutical Processes
Mycoplasma contamination can have a devastating effect on drug manufacturers but what are the factors make a bioprocess vulnerable to Mycoplasma contamination and what measures can be put in place to...
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Listening, Learning and Applying Knowledge in Product Development
Although bulk filtration of a product prior to shipping was one of the first bioprocessing steps to benefit from single-use technology, it has been one of the last to benefit from...
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Early Adoption Single-Use Technology Can Ensure Successful Process Scale-Up
Whether you are running a process in a 30,000 L bioreactor in fed-batch mode, a 200 L continuous process, or have scaled-out (rather than up), you will start at small scale and look to increase the...
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Making Connections? Make the Right Choice for Your Single-Use Process
Single-use solutions have been widely adopted on a global scale within the biopharmaceutical industry due to the many advantages and process improvements they offer. Key applications for single-use...
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Extractables and Leachables - a Source of Confusion?
In the biopharmaceutical industry, extractables and leachables have come under the spotlight as stainless steel manufacturing systems have given way to single-use assemblies in...
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A Guide to Biopharmaceutical Filter Qualification
Filter qualification typically involves demonstrating bacterial retention of a filter under process simulated conditions. A crucial first step in this is in the hands of the filter vendor, who...
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Automating and Enclosing Bulk Fill Operations - the Way Forward?
The consequences of failure during downstream processing are severe. Following the Affinity Chromatography stage, the value of the product increases significantly at every step. A failure at the final...
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