Bioprocessing & Pharmaceutical Filtration

Is Standardization Possible in a Custom Single-use World? | Poll Results

A recent Parker domnick hunter webinar discussed the question "Is Standardization Possible in a Custom Single-use World?". The webinar looked at how high levels of customization has led to...
On July 18, 2016

How to Scale-up Pharmaceutical Filtration Systems | Case Study

For biomanufacturers, using a structured, analytical approach to process scale-up will breed confidence and ensure quality.    By adopting robust experimental design, results gleaned during initial...
On July 7, 2016

Effective Filtration of Biopharmaceutical Buffers

Buffers are used throughout the production of pharmaceuticals and buffer filtration is essential in protecting downstream chromatography and ultrafiltration equipment, controlling bioburden throughout...
On May 17, 2016

The Role of Prefiltration in the Optimization of Bioprocess Filtration Systems

Filtration is commonly used in biopharmaceutical manufacturing in order to control bioburden within the production process, and the appropriate use of prefilters can help to optimize filtration costs....
On March 3, 2016

A Case Study for Collaborative Filter Product Development

Parker domnick hunter is committed to increasing productivity and customer satisfaction through application-driven new product development, and collaboration is a highly effective way in which to...
On March 3, 2016

Controlling Supply Chain and Process Risk During Biomanufacturing

Imagine the scenario: an insulin production facility is forced to shut down, or production ceases, limiting the availability of insulin to diabetics around the world. It’s a disturbing picture and...
On February 24, 2016

How to Select the Right Filter for Your Bioprocess

Selection of the appropriate filter product for a given application in your bioprocess is critical, as an incorrect decision at the specification stage may have significant economic, quality...
On October 12, 2015

What is Sterilizing Filtration and Why is it Important?

Sterilizing filtration is now commonplace in pharmaceutical manufacturing and is used in order to prevent microbial contamination from negatively impacting drug quality and, more importantly, to...
On September 3, 2015

Single-Use Technologies That Maximize Bioprocess Asset Use

There is increasing need to manufacture biopharmaceuticals more efficiently and cost-effectively due to downwards price pressures caused by trends such as the emergence of the market for biosimilars....
On August 4, 2015

Best Practices for Developing Single-Use TFF Steps

Single-use tangential flow filtration (TFF) technology offers a range of benefits in ultrafiltration and microfiltration applications in bioprocessing. While manufacturers have to fit a process around...
On June 15, 2015

Why You Should Consider Hollow Fibres for Ultrafiltration

According to conventional wisdom within the biopharmaceutical industry, cassettes are the most suitable tangential flow filtration (TFF) technology for ultrafiltration applications such as protein or...
On June 4, 2015

Is Innovation the Key to a Single-Use TFF Future?

Advances in technology are allowing biomanufacturers to move to entirely single-use set-ups for tangential flow filtration and benefit from the many advantages of single-use technology. Tangential...
On April 23, 2015

How to Successfully Scale-Up Automated Single-Use Bioprocesses

Speed to market is critical for biomanufacturers. The faster a process can be scaled-up, the faster a return on investment on drug development costs can be realized. With a strong trend towards...
On March 23, 2015

5 Benefits of Single-Use Technology vs Stainless Steel

Single-use technology is quickly gaining in popularity around the world because of the financial and operational benefits over traditional process methods using stainless steel.  So, why should a...
On February 27, 2015

7 Tips for Successful QbD Implementation in Biomanufacturing

If quality by design (QbD) promises a more efficient manufacturing process with more consistent product quality and increased safety, why is there reluctance among the bioprocessing industry...
On January 27, 2015

How to Minimize the Risk of Mycoplasma Contamination

Mycoplasma may be the smallest class of free-living microorganism, but the consequences of contamination in a cell batch can be huge with manufacturers suffering reduced yields and lost...
On December 22, 2014

A Strategy for Avoiding Manual Errors in Biomanufacturing

Bioprocess variation attributed to operator error can be costly, leading to decreased process efficiency and reduced product quality. The application of the skill, rule & knowledge (SRK) framework...
On November 27, 2014

10 Things to Consider When Assessing Your Single-Use Bioprocess Automation Requirements

When implementing a single-use bioprocessing solution, various levels of automation are available from completely manual steps, through semi-automated to completely automated unit operations....
On November 10, 2014

Can Process Control Impact the Effectiveness of Mycoplasma Filtration?

Mycoplasma contamination events, although infrequent, can have an enormous and immediate negative impact in terms of lost product batches, in addition to longer-term restrictions upon...
On November 3, 2014

Automation of Final Bulk Filtration and Container Fill Step in GMP Environment

Automating a bioprocess step reduces process variation, increases productivity, prevents manual errors and frees up operator time, as well as improving health & safety and working conditions....
On October 22, 2014