Author Filtration Team
“It takes 20 years to build a reputation and five minutes to ruin
it”. Wise words from Warren Buffet. And in biopharmaceutical
manufacturing, these words certainly ring true. Process variation
or...
Posted On 03/31/2020
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The principles and practices of lean manufacturing are widely used
in industries across the globe to continuously improve processes,
drive efficiencies and reduce costs. Even in...
Posted On 03/19/2020
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When compared to bacterial contamination, Mycoplasma contamination
isn't immediately obvious. The outcome of any contamination event
is the same — the disposal of the contaminated media...
Posted On 03/10/2020
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In a world where we measure on-time delivery, is 98
percent really acceptable? It sounds good but in the supply
chain of the pharmaceutical industry, what is the impact on the 2
percent of patients...
Posted On 03/04/2020
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Mycoplasma contamination poses a serious threat to
biopharmaceutical manufacturers. But it's the specific
characteristics of Mycoplasma that make it such a challenge.
Mycoplasma characteristics differ...
Posted On 02/11/2020
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Mycoplasma contamination can have a devastating effect on drug
manufacturers but what are the factors make a bioprocess vulnerable
to Mycoplasma contamination and what measures can be put in place
to...
Posted On 02/04/2020
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Although bulk filtration of a product prior to shipping was one of
the first bioprocessing steps to benefit from single-use
technology, it has been one of the last to benefit from...
Posted On 11/21/2019
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Whether you are running a process in a 30,000 L bioreactor in
fed-batch mode, a 200 L continuous process, or have scaled-out
(rather than up), you will start at small scale and look to
increase the...
Posted On 10/30/2019
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Single-use solutions have been widely adopted on a global scale
within the biopharmaceutical industry due to the many advantages
and process improvements they offer. Key applications for
single-use...
Posted On 10/15/2019
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In the biopharmaceutical industry, extractables and leachables have
come under the spotlight as stainless steel manufacturing systems
have given way to single-use assemblies in...
Posted On 10/07/2019
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Parker's Technical Support Group works hand in hand with customers
to help them overcome operational challenges and optimize their
filtration systems. We build close relationships with...
Posted On 05/28/2019
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Filter qualification typically involves demonstrating bacterial
retention of a filter under process simulated conditions. A crucial
first step in this is in the hands of the filter vendor, who...
Posted On 05/15/2019
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Filter blockages in a beer production process can cause serious
problems for breweries which can include increased expenditure on
replacement filter cartridges and a significant amount of downtime
in...
Posted On 05/09/2019
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The consequences of failure during downstream processing are
severe. Following the Affinity Chromatography stage, the value of
the product increases significantly at every step. A failure at the
final...
Posted On 01/17/2019
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Mycoplasma contamination events, although rare, can have an
enormous and immediate negative impact on biomanufacturers leading
to reduced productivity and delays in products
reaching patients. Parker...
Posted On 01/07/2019
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When it comes to the use of sterile gas for product contact
purposes – such as aseptic packaging or product purge applications
– no clear guidelines have been adopted by the dairy industry
regarding...
Posted On 01/04/2019
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Bacterial contamination in the dairy industry can have major
implications for operators. It can result in product re-work,
wastage or recall – the cost of which can run into millions of
pounds once...
Posted On 12/18/2018
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As the brewing industry is becoming more competitive, breweries of
all sizes realize the importance of producing a higher quality
product while keeping an eye on the bottom line at the same time.
When...
Posted On 11/20/2018
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The dairy industry is currently enjoying a period of growth,
principally driven by a shift in consumer preference towards
protein-heavy diets as opposed to carbohydrates and an increase in
the average...
Posted On 09/23/2018
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One of the challenges faced in any biopharmaceutical process is
bioburden control and containment — or how do you keep what is out,
"out" and what is in "in". For a stainless steel-based
manufacturing...
Posted On 09/13/2018
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