Bioreactors are playing a growing and ever more important role in the biopharmaceutical arena and life sciences. Their role within the research of pharmaceuticals and antibodies is contributing to new drug discovery and the development of improved production capabilities for new vaccines and therapeutics.
Bioreactors being used in a growing number of applications
Reusable Bioreactors made of stainless steel and Single-Use Bioreactors (SUBs) are being used in a growing number of research and manufacturing applications. Their particular characteristics include low maintenance requirements, fast turnaround times and low energy consumption. These factors are making the use of Bioreactors particularly critical in research and manufacturing applications of mammalian and insect cell cultures.
When developing its new leading edge supply and control tower, a world leading manufacturer of bioreactors and fermentors for the biopharmaceutical industry required a fittings and tubing solution that would convey all the different gases, whilst being certified for the use with oxygen and that would be operationally efficient as well as cost-effective.
Compatible solutions for the supplying tower to feed the bioreactors and gas conveyance.
Working closely with experts from Parker Legris, the manufacturer’s design team was able to test and select a compatible solution for the supplying tower to feed the bioreactors with all the required gasses and oxygen (including air, O2, N2, CO2).
“Parker's supplied solution was based on its fully certificated range of CleanFit push-in fittings and tubing, and provides the complete circuit for fluid management. The solution went through a full qualification process that included 6 months of testing and the results fully validated the solution as compliant with all the required technical specifications in terms of cleanliness, sealing, security and price.”
Laurent Orcibal, CleanFit Product Manager at Parker.
The only other connectors or tubes able to provide equivalent certification for oxygen use were stainless steel products, which are not only more expensive but also less flexible. This solution also offers an easier assembly during the manufacturing process and easier modifications and adjustment throughout the life of the bioreactor.
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Article contributed by Thomas Mayer, Parker Life Sciences, Parker Hannifin Germany.
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