Author Filtration Team
As the benefits of single-use became clear and the technology
became established in the 2000s, there was a drive to utilize it in
more process steps. Single-use was being utilized in steps...
Posted On 06/22/2020
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Author Filtration Team
Human error in bioprocessing can have serious consequences for
biopharmaceutical manufacturers. Accidents can cause a health
hazard for staff involved in bioprocessing operations and human
error can...
Posted On 06/09/2020
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Author Filtration Team
The Parker Filtration Innovation Center houses the research and
development for all of Parker Hannifin's filtration products.
This 82,000 square foot facility is dedicated solely to the
discovery of...
Posted On 05/21/2020
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Author Filtration Team
A biopharmaceutical customer was reviewing its process for tryptone
soya broth (TSB) and vegetable soya broth (VSB) production.
The existing process incorporated five-step filtration, using...
Posted On 04/08/2020
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Author Filtration Team
“It takes 20 years to build a reputation and five minutes to ruin
it”. Wise words from Warren Buffet. And in biopharmaceutical
manufacturing, these words certainly ring true. Process variation
or...
Posted On 03/31/2020
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The principles and practices of lean manufacturing are widely used
in industries across the globe to continuously improve processes,
drive efficiencies and reduce costs. Even in...
Posted On 03/19/2020
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When compared to bacterial contamination, Mycoplasma contamination
isn't immediately obvious. The outcome of any contamination event
is the same — the disposal of the contaminated media...
Posted On 03/10/2020
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In a world where we measure on-time delivery, is 98
percent really acceptable? It sounds good but in the supply
chain of the pharmaceutical industry, what is the impact on the 2
percent of patients...
Posted On 03/04/2020
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Mycoplasma contamination poses a serious threat to
biopharmaceutical manufacturers. But it's the specific
characteristics of Mycoplasma that make it such a challenge.
Mycoplasma characteristics differ...
Posted On 02/11/2020
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Mycoplasma contamination can have a devastating effect on drug
manufacturers but what are the factors make a bioprocess vulnerable
to Mycoplasma contamination and what measures can be put in place
to...
Posted On 02/04/2020
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Although bulk filtration of a product prior to shipping was one of
the first bioprocessing steps to benefit from single-use
technology, it has been one of the last to benefit from...
Posted On 11/21/2019
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Whether you are running a process in a 30,000 L bioreactor in
fed-batch mode, a 200 L continuous process, or have scaled-out
(rather than up), you will start at small scale and look to
increase the...
Posted On 10/30/2019
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Single-use solutions have been widely adopted on a global scale
within the biopharmaceutical industry due to the many advantages
and process improvements they offer. Key applications for
single-use...
Posted On 10/15/2019
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In the biopharmaceutical industry, extractables and leachables have
come under the spotlight as stainless steel manufacturing systems
have given way to single-use assemblies in...
Posted On 10/07/2019
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Parker's Technical Support Group works hand in hand with customers
to help them overcome operational challenges and optimize their
filtration systems. We build close relationships with...
Posted On 05/28/2019
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Filter qualification typically involves demonstrating bacterial
retention of a filter under process simulated conditions. A crucial
first step in this is in the hands of the filter vendor, who...
Posted On 05/15/2019
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Filter blockages in a beer production process can cause serious
problems for breweries which can include increased expenditure on
replacement filter cartridges and a significant amount of downtime
in...
Posted On 05/09/2019
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The consequences of failure during downstream processing are
severe. Following the Affinity Chromatography stage, the value of
the product increases significantly at every step. A failure at the
final...
Posted On 01/17/2019
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Mycoplasma contamination events, although rare, can have an
enormous and immediate negative impact on biomanufacturers leading
to reduced productivity and delays in products
reaching patients. Parker...
Posted On 01/07/2019
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When it comes to the use of sterile gas for product contact
purposes – such as aseptic packaging or product purge applications
– no clear guidelines have been adopted by the dairy industry
regarding...
Posted On 01/04/2019
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