Author Filtration Team
Biopharmaceutical manufacturers have traditionally implemented bulk
final filtration and bulk dispensing as two separate unit
operations – with multiple operators assigned to carrying them
out....
Posted On 10/15/2020
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Author Filtration Team
In bulk dispense operations, filtration can sometimes be treated as
either a completely separate unit operation or in some systems as a
bolt-on – an optional module that while performing this
critical...
Posted On 09/03/2020
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Author Filtration Team
Cell culture media is a key component of upstream bioprocessing
needed to encourage the growth and survival of cells. This is vital
to achieving a viable cell density and, ultimately, the...
Posted On 07/28/2020
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Author Filtration Team
The microbial stabilization of beer is of critical
importance for the shelf-life of beers – and as beers are
exported all over the world, it’s vital that their original
characteristics still remain...
Posted On 07/27/2020
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Author Filtration Team
Single-use technology has major benefits for the biopharmaceutical
manufacturing industry. It enables rapid turnaround times between
batches and allows facilities to be multi-product while...
Posted On 07/21/2020
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Author Filtration Team
As the benefits of single-use became clear and the technology
became established in the 2000s, there was a drive to utilize it in
more process steps. Single-use was being utilized in steps...
Posted On 06/22/2020
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Author Filtration Team
Human error in bioprocessing can have serious consequences for
biopharmaceutical manufacturers. Accidents can cause a health
hazard for staff involved in bioprocessing operations and human
error can...
Posted On 06/09/2020
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Author Filtration Team
The Parker Filtration Innovation Center houses the research and
development for all of Parker Hannifin's filtration products.
This 82,000 square foot facility is dedicated solely to the
discovery of...
Posted On 05/21/2020
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Author Filtration Team
A biopharmaceutical customer was reviewing its process for tryptone
soya broth (TSB) and vegetable soya broth (VSB) production.
The existing process incorporated five-step filtration, using...
Posted On 04/08/2020
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Author Filtration Team
“It takes 20 years to build a reputation and five minutes to ruin
it”. Wise words from Warren Buffet. And in biopharmaceutical
manufacturing, these words certainly ring true. Process variation
or...
Posted On 03/31/2020
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Author Filtration Team
The principles and practices of lean manufacturing are widely used
in industries across the globe to continuously improve processes,
drive efficiencies and reduce costs. Even in...
Posted On 03/19/2020
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Author Filtration Team
When compared to bacterial contamination, Mycoplasma contamination
isn't immediately obvious. The outcome of any contamination event
is the same — the disposal of the contaminated media...
Posted On 03/10/2020
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Author Filtration Team
In a world where we measure on-time delivery, is 98
percent really acceptable? It sounds good but in the supply
chain of the pharmaceutical industry, what is the impact on the 2
percent of patients...
Posted On 03/04/2020
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Author Filtration Team
Mycoplasma contamination poses a serious threat to
biopharmaceutical manufacturers. But it's the specific
characteristics of Mycoplasma that make it such a challenge.
Mycoplasma characteristics differ...
Posted On 02/11/2020
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Author Filtration Team
Mycoplasma contamination can have a devastating effect on drug
manufacturers but what are the factors make a bioprocess vulnerable
to Mycoplasma contamination and what measures can be put in place
to...
Posted On 02/04/2020
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Author Filtration Team
When sizing chillers for an application, it is necessary to ensure
the unit adequately sized to handle maximum process loads in
worst-case site conditions. However, customers may fail to plan...
Posted On 12/11/2019
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Author Filtration Team
Although bulk filtration of a product prior to shipping was one of
the first bioprocessing steps to benefit from single-use
technology, it has been one of the last to benefit from...
Posted On 11/21/2019
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Author Filtration Team
Whether you are running a process in a 30,000 L bioreactor in
fed-batch mode, a 200 L continuous process, or have scaled-out
(rather than up), you will start at small scale and look to
increase the...
Posted On 10/30/2019
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Author Filtration Team
Single-use solutions have been widely adopted on a global scale
within the biopharmaceutical industry due to the many advantages
and process improvements they offer. Key applications for
single-use...
Posted On 10/15/2019
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Author Filtration Team
In the biopharmaceutical industry, extractables and leachables have
come under the spotlight as stainless steel manufacturing systems
have given way to single-use assemblies in...
Posted On 10/07/2019
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