Process Filtration
How Automation Takes Single-Use Technology to the Next Level
As the benefits of single-use became clear and the technology became established in the 2000s, there was a drive to utilize it in more process steps. Single-use was being utilized in steps...
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Reducing Human Error in Bioprocessing
Human error in bioprocessing can have serious consequences for biopharmaceutical manufacturers. Accidents can cause a health hazard for staff involved in bioprocessing operations and human error can...
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Innovation Center Delivers Filtration Engineering Breakthroughs
The Parker Filtration Innovation Center houses the research and development for all of Parker Hannifin's filtration products. This 82,000 square foot facility is dedicated solely to the discovery of...
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Optimizing a Cell Culture Media Filtration Process | Case Study
A biopharmaceutical customer was reviewing its process for tryptone soya broth (TSB) and vegetable soya broth (VSB) production. The existing process incorporated five-step filtration, using...
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Standardization and Control - Protecting Your People, Product and Reputation
“It takes 20 years to build a reputation and five minutes to ruin it”. Wise words from Warren Buffet. And in biopharmaceutical manufacturing, these words certainly ring true. Process variation or...
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Improve Accuracy and Efficiency by Tackling the Eight Wastes of Lean
The principles and practices of lean manufacturing are widely used in industries across the globe to continuously improve processes, drive efficiencies and reduce costs. Even in...
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Mycoplasma Contamination - Detection and Elimination
When compared to bacterial contamination, Mycoplasma contamination isn't immediately obvious. The outcome of any contamination event is the same — the disposal of the contaminated media...
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Preventing Product Losses During Biopharmaceutical Manufacturing
In a world where we measure on-time delivery, is 98 percent really acceptable? It sounds good but in the supply chain of the pharmaceutical industry, what is the impact on the 2 percent of patients...
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Mycoplasma Contamination - Why So Serious?
Mycoplasma contamination poses a serious threat to biopharmaceutical manufacturers. But it's the specific characteristics of Mycoplasma that make it such a challenge. Mycoplasma characteristics differ...
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Tackling the Source of Mycoplasma Contamination in Biopharmaceutical Processes
Mycoplasma contamination can have a devastating effect on drug manufacturers but what are the factors make a bioprocess vulnerable to Mycoplasma contamination and what measures can be put in place to...
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Listening, Learning and Applying Knowledge in Product Development
Although bulk filtration of a product prior to shipping was one of the first bioprocessing steps to benefit from single-use technology, it has been one of the last to benefit from...
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Early Adoption Single-Use Technology Can Ensure Successful Process Scale-Up
Whether you are running a process in a 30,000 L bioreactor in fed-batch mode, a 200 L continuous process, or have scaled-out (rather than up), you will start at small scale and look to increase the...
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Making Connections? Make the Right Choice for Your Single-Use Process
Single-use solutions have been widely adopted on a global scale within the biopharmaceutical industry due to the many advantages and process improvements they offer. Key applications for single-use...
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Extractables and Leachables - a Source of Confusion?
In the biopharmaceutical industry, extractables and leachables have come under the spotlight as stainless steel manufacturing systems have given way to single-use assemblies in...
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Supporting Bottling Operations in the Wine Industry
Parker's Technical Support Group works hand in hand with customers to help them overcome operational challenges and optimize their filtration systems. We build close relationships with...
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A Guide to Biopharmaceutical Filter Qualification
Filter qualification typically involves demonstrating bacterial retention of a filter under process simulated conditions. A crucial first step in this is in the hands of the filter vendor, who...
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Putting Filter Blockages Under the Microscope
Filter blockages in a beer production process can cause serious problems for breweries which can include increased expenditure on replacement filter cartridges and a significant amount of downtime in...
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Automating and Enclosing Bulk Fill Operations - the Way Forward?
The consequences of failure during downstream processing are severe. Following the Affinity Chromatography stage, the value of the product increases significantly at every step. A failure at the final...
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Mycoplasma Contamination: Understanding the Risks and Taking on the Challenges
Mycoplasma contamination events, although rare, can have an enormous and immediate negative impact on biomanufacturers leading to reduced productivity and delays in products reaching patients. Parker...
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Reduce Microbial Hazards in Dairy Manufacturing with Pharmaceutical Best Practices
When it comes to the use of sterile gas for product contact purposes – such as aseptic packaging or product purge applications – no clear guidelines have been adopted by the dairy industry regarding...
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